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| 1493 |
| | The Nuremberg Chronicle integrates text and pictures in an ambitious history of the world | |
| | Nuremberg Chronicle Fotofile CG
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| c. 1495 |
| | Dürer, the first great artist to tackle the complexities of printing, becomes a master of woodcut and engraving | |
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| c. 1500 |
| | The first etchings are printed in Augsburg, from iron plates | |
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| c. 1500 |
| | The first watches, made in Nuremberg, are spherical clocks about three inches in diameter, worn usually on a ribbon round the neck | |
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| 1517 |
| | The local sale of indulgences by Johann Tetzel outrages a friar teaching in Wittenberg, Martin Luther | |
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| 1517 |
| | Martin Luther nails his 95 Theses to the door of the castle church in Wittenberg | |
| | Woodcut portrait of Martin Luther National Archives, Kew
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| 1518 |
| | Philipp Melanchthon joins the Wittenberg university to teach Greek and inspires Luther to translate the New Testament | |
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| c. 1520 |
| | Europe's new printing presses make possible the first pamphlet war, spreading instant arguments for and against the Reformation | |
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| 1520 |
| | Luther's writings are burnt in Rome by order of the pope | |
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| 1521 |
| | Pope Leo X excommunicates Martin Luther after he has refused to recant | |
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